Europa League holders Atletico Madrid were eliminated by Russian side Rubin despite winning 1-0 away from home. The Russian side went through because of a 2-0 victory in the first leg at Vicente Calderon meaning the final aggregate score was 2-1 in favor of the Russian side.
Tottenham Hotspur reached the final 16 with a dramatic 1-1 draw at Lyon. Mousa Dembélé popped up with a stunning last-minute goal to secure a 1-1 draw at Lyon and a 3-2 win on aggregate. They will play Inter Milan in the next round.
Inter went through thanks to a 5-0 aggregate win over Romanian side CFR Cluj. Fredy Guarin scored twice and Marco Benassi added a late third as the Italians comfortably added to their 2-0 lead from the first leg. Cluj were forced to play the closing minutes with 10 men after Mario Camora's dismissal.
Newcastle United secured a 1-0 aggregate win over Ukranian side Metalist Kharkiv with a Shola Ameobi penalty. It was Ameobi's 15th European goal. They will play Anzhi Makhachkala in the next round.
Benfica saw off Bayer Leverkusen 3-1 on aggregate in their encounter in Portugal. Benfica held a 1-0 lead from the first leg in Germany thanks to Oscar Cardozo's goal and their lead was doubled when Ola John found the net after an hour. Andre Schurrle equalised for Leverkusen on the night with 15 minutes to go but Benfica restored their two-goal cushion two minutes later through Nemanja Matic.
Benfica next play Bordeaux, who progressed after a 2-1 aggregate win over Dynamo Kyiv. A solitary goal by Cheik Diabate shortly before half-time was enough to guide Bordeaux through after the first leg in Ukraine ended 1-1.