Wentworth Miller is still best known for his role in 'Prison Break', even though it's been several years since the series went off the air. Playing Michael Scofield certainly brought Miller fame and fortune, and though the show ran from 2005 to 2009, it made enough of an impression that its actors more or less became household names.

Wentworth Miller is best known for Prison Break
Since the show, Miller seems to have taken a break from acting, and gone into screenwriting. He did guest star on Law and Order: SVU in 2009, and he had a supporting role in Resident Evil: Afterlife in 2010.
He also guest starred in 'House M.D.' in 2011, and also made a guest appearance in the TV series 'Young Justice' earlier this year. Despite that, his most high-profile job after wrapping on 'Prison Break' has been writing the film 'Stoker', which released earlier this year and starred Mia Wasikowska and Nicole Kidman.

Wentworth Miller in a still from Prison Break
Directed by Chan-wook Park, the film got strong reviews and proved that Miller has a lot of talent in the screenwriting department. While he does have a major role in a thriller coming out later this year [The Loft], it looks like his future may lie in writing more than acting.
Wentworth Miller on Ellen